The crash happened just before 4pm on the Middle Road.
Two vehicles collided and rolled over.
The deceased is identified as 38-year-old Julie Maloy of Rangley. Police say she was thrown from the pick up truck, which was registered in her name.
The driver of the other car, 37-year-old Ginger St. Pierre of Sidney, was taken to maine general hospital in Waterville.
No word yet on the extent of her injuries.
The road was shut down for four hours while state police reconstructed the crash.