It began just before 2 o’clock Monday morning, when a pair of vehicles collided near mile marker 117.
State Police say 53-year-old Jeffery Blais of Augusta was headed the wrong way on the interstate.
He slammed head on into a smaller car driven by 32-year-old Shannon Casey of Portland.
Police say Blazer’s vehicle veered off the road, caught on fire, and rolled into a tree.
Blazer was killed in the crash.
Casey was critically injured.
Seven miles of the turnpike on the southbound side were shut down for several hours, while police investigated.