State police say 40-year-old Heather Barrows died at the scene when her car was struck while travelling along the Palmyra Road.
The crash happened just before 7 pm Thursday night.
According to the police report, 49-year-old Estella Briel of Cambridge was headed in the opposite direction when her car went off the pavement.
Briel lost control, and her S.U.V. crossed the center line, hitting Barrows head on.
Briel was not hurt in the crash.